It hasn't been offiicially confirmed but the indications that President Obama's speech to the Islamic world will be made from Cairo University are increasing, including the apparent massive cleanup and facelift of the university and its assembly hall. While I was one of those who thought al-Azhar would be more appropriate, Cairo University is still much preferable to speaking in a government building, or at some military parade ground or protected zone like Sharm al-Sheikh. It is a state institution but speaking there does not directly seem to endorse the regime's more controversial aspects. Rather it emphasizes the importance of education in the Arab and Muslim world.
Founded in 1908 as the Egyptian University, it was later known as Fuad I University until the fall of the monarchy, when it became Cairo University.